Obesity has emerged as the largest public health issue in recent history, with important implications for Chronic Kidney Disease. In addition, obesity not only increases the risk for Chronic Kidney Disease (CKD) but also its progression to End Stage Renal Disease (ESRD), i.e. kidney failure requiring dialysis.
There is a strong link between decreased physical activity and obesity. It has been suggested That a sedentary lifestyle should be regarded as a disease on its own. Adding to sedentary lifestyle, increased consumption of junk food more energy-dense food with high glycemic index and the introduction of high-fructose corn syrup in soft drinks may be contributing to not only the obesity epidemic.
The most common method for defining obesity is based on BMI (i.e., a person’s weight [kilograms] divided by the square of his or her height [meters]). The World Health Organization (WHO) considers a BMI between 20 and 25 kg/m2 as normal weight, a BMI between 25 and 30 kg/m2 as overweight, and a BMI of >30 kg/m2 as obese.
Why Do We Get Fat?
Microalbuminuria (i.e. leakage of albumin in urine) is one of the earliest signs of kidney disease and Obesity is associated with a 70% increased risk of microalbuminuria compared to lean subjects.
Increased presence of Diabetes Mellitus, Hypertension and atherosclerosis indirectly does increase the incidence of kidney disease in the overwieight & obese.
However, there are also direct ways in which kidneys get affected by obesity. Increased fat mass leads to increased metabolic demand on the kidneys that increases the stress on kidneys.